Interactions between the combined genotypes of 5-HTTLPR and BDNF Val66Met polymorphisms and parenting on adolescent depressive symptoms: A three-year longitudinal study.

Abstract excerpt

BACKGROUND: The importance of multiple genes-environment interaction (G × E) has been highlighted in studies on depressive symptoms. 5-HTTLPR and BDNF Val66Met polymorphisms, with functional interconnection, have been implicated in the pathophysiology of depressive symptoms. However, little is understood about whether the interaction of 5-HTTLPR, BDNF Val66Met and parenting fits better with the epistatic or...

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