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Article

Cytochrome P450 3A4FNx011B as pharmacogenomic predictor of tacrolimus pharmacokinetics and clinical outcome in the liver transplant recipients.

Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association - 1 Jan 2000

Albekairy Abdulkareem, Alkatheri Abdulmalik, Fujita Shiro, Hemming Alan, Howard Richard, Reed Alan, Karlix Janet

Abstract excerpt

BACKGROUND AND AIMS: Tacrolimus is a macrolide immunosuppressant used for prevention of allograft rejection in organ transplantation and metabolized in the liver and intestine by cytochrome P450 3A4 (CYP3A4) enzyme. A single nucleotide polymorphism (SNP) in the CYP3A4 promoter region has been identified. It has been shown that the presence of CYP3A4FNx011B allele (variant GG) is associated with a reduced...

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Identifiers

PMID: 23481136
DOI: 10.4103/1319-3767.108484
PMCID: PMC3632017

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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