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Article

Influence of SLCO1B3 genetic variations on tacrolimus pharmacokinetics in renal transplant recipients.

Drug metabolism and pharmacokinetics - 1 Jan 2013

Boivin Andrée-Anne, Cardinal Héloïse, Barama Azemi, Naud Judith, Pichette Vincent, Hébert Marie-Josée, Roger Michel

Abstract excerpt

The immunosuppressive drug tacrolimus requires strict therapeutic monitoring due to its narrow therapeutic index and high interindividual variability. Organic anion transporting polypeptide 1B3 (OATP1B3) is a human hepatocyte transporter involved in the hepatobiliary elimination of diverse endogenous and exogenous substances. Genetic variations within the solute carrier (SLCO) 1B3 gene that encodes OATP1B3 may...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 23149872
DOI: 10.2133/dmpk.dmpk-12-sh-093

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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