Article
CYP3A5 and POR gene polymorphisms as predictors of infection and graft rejection in post-liver transplant patients treated with tacrolimus - a cohort study.
The pharmacogenomics journal - 25 Feb 2025
Naldi Graziella D' Agostino Ribeiro, Minari Ariane Boccoli, Pereira Thales D M, Fossaluza Victor, Eugenio Nicholas Wagner, Ferreira Marcelo Alves, Gregório Guilherme H, Nacif Lucas, D Albuquerque Luiz Augusto Carneiro, di Lazzaro Filho Ricardo, Cançado Eduardo Luiz Rachid, Ono Suzane Kioko
Abstract excerpt
Liver transplantation is the only curative option for patients with advanced stages of liver disease, with tacrolimus used as the immunosuppressive drug of choice. Genetic variability can interfere with drug response, potentially leading to overexposure or underexposure. This study aims to investigate the association of CYP3A4 (rs2740574, rs2242480, rs35599367), CYP3A5 (rs776746, ), POR () and...