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Article

Patient-derived xenografts recapitulate molecular features of human uveal melanomas.

Molecular oncology - 1 Jun 2013

Laurent Cécile, Gentien David, Piperno-Neumann Sophie, Némati Fariba, Nicolas André, Tesson Bruno, Desjardins Laurence, Mariani Pascale, Rapinat Audrey, Sastre-Garau Xavier, Couturier Jérôme, Hupé Philippe, de Koning Leanne, Dubois Thierry, Roman-Roman Sergio, Stern Marc-Henri, Barillot Emmanuel, Harbour J William, Saule Simon, Decaudin Didier

Abstract excerpt

We have previously developed a new method for the development and maintenance of uveal melanoma (UM) xenografts in immunodeficient mice. Here, we compare the genetic profiles of the primary tumors to their corresponding xenografts that have been passaged over time. The study included sixteen prim...

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Source

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Identifiers

PMID: 23478236
DOI: 10.1016/j.molonc.2013.02.004
PMCID: PMC4966164

Genes

BAP1
BRAF
GNA11
GNA15
GNAQ
GNAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23478236-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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