Article
Genetic and molecular characterization of uveal melanoma cell lines.
Pigment cell & melanoma research - 1 Mar 2012
Griewank K G, Yu X, Khalili J, Sozen M M, Stempke-Hale K, Bernatchez C, Wardell S, Bastian B C, Woodman S E
Abstract excerpt
The recent identification of frequent activating mutations in GNAQ or GNA11 in uveal melanoma provides an opportunity to better understand the pathogenesis of this melanoma subtype and to develop rational therapeutics to target the cellular effects mediated by these mutations. Cell lines from uveal melanoma tumors are an essential tool for these types of analyses. We report the mutation status of relevant...
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