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Article

Endothelin-2-mediated protection of mutant photoreceptors in inherited photoreceptor degeneration.

PloS one - 1 Jan 2013

Bramall Alexa N, Szego Michael J, Pacione Laura R, Chang Inik, Diez Eduardo, D'Orleans-Juste Pedro, Stewart Duncan J, Hauswirth William W, Yanagisawa Masashi, McInnes Roderick R

Abstract excerpt

Expression of the Endothelin-2 (Edn2) mRNA is greatly increased in the photoreceptors (PRs) of mouse models of inherited PR degeneration (IPD). To examine the role of Edn2 in mutant PR survival, we generated Edn2(-/-) mice carrying homozygous Pde6b(rd1) alleles or the Tg(RHO P347S) transgene. In the Edn2(-/-) background, PR survival increased 110% in Pde6b(rd1/rd1) mice at post-natal (PN) day 15, and 60% in...

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Share to Cell Hypoxia
Share to Cyclic Nucleotide Phosphodiesterases, Type 6

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fibroblast Growth Factor 2

Share to Photoreceptor Cells, Vertebrate

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Source

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Identifiers

PMID: 23469133
DOI: 10.1371/journal.pone.0058023
PMCID: PMC3585171

Genes

RHO
EDN2
FGF2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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