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Article

An Exon Splice Enhancer Primes IGF2:IGF2R Binding Site Structure and Function Evolution

29 Nov 2012

Abstract excerpt

Placental development and genomic imprinting coevolved with parental conflict over resource distribution to mammalian offspring. The imprinted genes IGF2 and IGF2R code for the growth promoter insulin-like growth factor 2 (IGF2) and its inhibitor, mannose 6-phosphate (M6P)/IGF2 receptor (IGF2R), respectively. M6P/IGF2R of birds and fish do not recognize IGF2. In monotremes, which lack imprinting, IGF2...

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PMID: 23197533
DOI: 10.1126/science.1228633

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