A sex-specific effect of the CYP17A1 SNP rs11191548 on blood pressure in Chinese children.

doi:10.1038/jhh.2011.96

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A sex-specific effect of the CYP17A1 SNP rs11191548 on blood pressure in Chinese children.

Journal of human hypertension - 1 Dec 2012

Wu L, Xi B, Zhang M, Shen Y, Zhao X, Wang T, Cheng H, Hou D, Liu G, Wang X, Mi J

Abstract excerpt

CYP17A1 gene encodes the cytochrome P450 enzyme CYP17A1, a key enzyme involved in steroid metabolism. A single nucleotide polymorphism (SNP) near CYP17A1, rs11191548, showed significant association with hypertension in European adults. However, this association has not been demonstrated in children thus far. Additionally, the role of CYP17A1 in elevating blood pressure (BP) is unclear. We investigated the...

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PMID: 22048715
DOI: 10.1038/jhh.2011.96

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