Associations of the hypertension-related single nucleotide polymorphism rs11191548 with high-density lipoprotein cholesterol and leptin in Chinese children.

doi:10.1186/s12881-018-0523-y

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Associations of the hypertension-related single nucleotide polymorphism rs11191548 with high-density lipoprotein cholesterol and leptin in Chinese children.

BMC medical genetics - 16 Jan 2018

Wu Lijun, Gao Liwang, Zhao Xiaoyuan, Zhang Meixian, Wu Jianxin, Mi Jie

Abstract excerpt

BACKGROUND: The genome-wide association study has founded hypertension-related single nucleotide polymorphism (SNP) rs11191548 near CYP17A1 encoding a key enzyme involved in steroid metabolism, but the molecular mechanisms are not understood and the associations of the SNP with hypertension-related traits are not fully described, especially in children. The aim of the present study is to investigate the...

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PMID: 29338791
DOI: 10.1186/s12881-018-0523-y
PMCID: PMC5771196

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