Article
PINK1 rendered temperature sensitive by disease-associated and engineered mutations.
Human molecular genetics - 1 Jul 2013
Narendra Derek P, Wang Chunxin, Youle Richard J, Walker John E
Abstract excerpt
Mutations in Parkin or PINK1 are the most common cause of recessively inherited parkinsonism. Parkin and PINK1 function in a conserved mitochondrial quality control pathway, in which PINK1, a putative mitochondrial kinase, directs Parkin, a cytosolic E3 ubiquitin ligase, selectively to dysfunctional mitochondria to promote their isolation, immobilization and degradation by macroautophagy (hereafter, mitophagy)....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.