Article
The Pseudomonas aeruginosa PhoP-PhoQ two-component regulatory system is induced upon interaction with epithelial cells and controls cytotoxicity and inflammation.
Infection and immunity - 1 Sept 2012
Gellatly Shaan L, Needham Brittany, Madera Laurence, Trent M Stephen, Hancock Robert E W
Abstract excerpt
The adaptation of Pseudomonas aeruginosa to its environment, including the host, is tightly controlled by its network of regulatory systems. The two-component regulatory system PhoPQ has been shown to play a role in the virulence and polymyxin resistance of P. aeruginosa as well as several other Gram-negative species. Dysregulation of this system has been demonstrated in clinical isolates, yet how it affects...
Topics
- Bacterial Adhesion
- Bacterial Proteins
- Cell Line
- Epithelial Cells
- Gene Expression Regulation, Bacterial
- Host-Pathogen Interactions
- Humans
- Inflammation
- Mutation
- Pseudomonas aeruginosa