Alterations in Two-Component Regulatory Systems of <i>phoPQ</i> and <i>pmrAB</i> Are Associated with Polymyxin B Resistance in Clinical Isolates of <i>Pseudomonas aeruginosa</i>

Abstract excerpt

Polymyxins are often the only option to treat acquired multidrug-resistant Pseudomonas aeruginosa. Polymyxin susceptibility in P. aeruginosa PAO1 is associated with the lipopolysaccharide structure that is determined by arnBCADTEF and modulated by phoPQ and pmrAB. We examined five clonally unrelated clinical isolates of polymyxin B-resistant P. aeruginosa to investigate the molecular basis of polymyxin...

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