Article
Genetic predictors of circulating 25-hydroxyvitamin d and risk of colorectal cancer.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Nov 2013
Hiraki Linda T, Qu Conghui, Hutter Carolyn M, Baron John A, Berndt Sonja I, Bézieau Stéphane, Brenner Hermann, Caan Bette J, Casey Graham, Chang-Claude Jenny, Chanock Stephen J, Conti David V, Duggan David, Fuchs Charles S, Gallinger Steven, Giovannucci Edward L, Harrison Tabitha A, Hayes Richard B, Hazra Aditi, Henderson Brian, Hoffmeister Michael, Hopper John L, Hudson Thomas J, Jenkins Mark A, Küry Sébastien, Le Marchand Loic, Lemire Mathieu, Ma Jing, Manson Joann E, Nan Hongmei, Newcomb Polly A, Ng Kimmie, Potter John D, Schoen Robert E, Schumacher Fredrick R, Seminara Daniela, Slattery Martha L, Wactawski-Wende Jean, White Emily, Wu Kana, Zanke Brent W, Kraft Peter, Peters Ulrike, Chan Andrew T
Abstract excerpt
BACKGROUND: Experimental evidence has demonstrated an antineoplastic role for vitamin D in the colon, and higher circulating 25-hydroxyvitamin D [25(OH)D] levels are consistently associated with a lower risk of colorectal cancer. Genome-wide association studies have identified loci associated with levels of circulating 25(OH)D. The identified single-nucleotide polymorphisms (SNPs) from four gene regions...
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