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Article

The CXC motif: a functional mimic of protein disulfide isomerase.

Biochemistry - 13 May 2003

Woycechowsky Kenneth J, Raines Ronald T

Abstract excerpt

Protein disulfide isomerase (PDI) utilizes the active site sequence Cys-Gly-His-Cys (CGHC; E degrees ' = -180 mV) to effect thiol-disulfide interchange during oxidative protein folding. Here, the Cys-Gly-Cys-NH(2) (CGC) peptide is shown to have a disulfide reduction potential (E degrees ' = -167 mV) that is close to that of PDI. This peptide has a thiol acid dissociation constant (pK(a) = 8.7) that is lower than...

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Identifiers

PMID: 12731880
DOI: 10.1021/bi026993q
PMCID: PMC2819094

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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