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Article

Catalytic mechanism of thiol peroxidase from Escherichia coli. Sulfenic acid formation and overoxidation of essential CYS61.

The Journal of biological chemistry - 14 Mar 2003

Baker Laura M S, Poole Leslie B

Abstract excerpt

Escherichia coli thiol peroxidase (Tpx, p20, scavengase) is part of an oxidative stress defense system that uses reducing equivalents from thioredoxin (Trx1) and thioredoxin reductase to reduce alkyl hydroperoxides. Tpx contains three Cys residues, Cys(95), Cys(82), and Cys(61), and the latter residue aligns with the N-terminal active site Cys of other peroxidases in the peroxiredoxin family. To identify the...

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PMID: 12514184
DOI: 10.1074/jbc.M209888200
PMCID: PMC3845838

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