Article
Effects of RAF inhibitors on PI3K/AKT signalling depend on mutational status of the RAS/RAF signalling axis.
Oncotarget - 16 Feb 2016
Fritsche-Guenther Raphaela, Witzel Franziska, Kempa Stefan, Brummer Tilman, Sers Christine, Blüthgen Nils
Abstract excerpt
Targeted therapies within the RAS/RAF/MEK/ERK signalling axis become increasingly popular, yet cross-talk and feedbacks in the signalling network lead to unexpected effects. Here we look systematically into how inhibiting RAF and MEK with clinically relevant inhibitors result in changes in PI3K/A...
Topics
- Apoptosis
- Benzimidazoles
- Blotting, Western
- Cell Proliferation
- Colonic Neoplasms
- Gene Expression Regulation, Neoplastic
- Humans
- MAP Kinase Signaling System
- Mutation
- Niacinamide
- Phenylurea Compounds
- Phosphatidylinositol 3-Kinases
- Phosphorylation
- Protein Kinase Inhibitors