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Article

ROCK inhibitor converts corneal endothelial cells into a phenotype capable of regenerating in vivo endothelial tissue.

The American journal of pathology - 1 Jul 2012

Okumura Naoki, Koizumi Noriko, Ueno Morio, Sakamoto Yuji, Takahashi Hiroaki, Tsuchiya Hideaki, Hamuro Junji, Kinoshita Shigeru

Abstract excerpt

Corneal endothelial dysfunction accompanied by visual disturbance is a primary indication for corneal transplantation. We previously reported that the adhesion of corneal endothelial cells (CECs) to a substrate was enhanced by the selective ROCK inhibitor Y-27632. It is hypothesized that the inhibition of ROCK signaling may manipulate cell adhesion properties, thus enabling the transplantation of cultivated CECs...

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Identifiers

PMID: 22704232
DOI: 10.1016/j.ajpath.2012.03.033

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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