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Autophagy and Cellular Senescence Mediated by Sox2 Suppress Malignancy of Cancer Cells

25 Feb 2013

Abstract excerpt

Autophagy is a critical cellular process required for maintaining cellular homeostasis in health and disease states, but the molecular mechanisms and impact of autophagy on cancer is not fully understood. Here, we found that Sox2, a key transcription factor in the regulation of the "stemness" of embryonic stem cells and induced-pluripotent stem cells, strongly induced autophagic phenomena, including intracellular...

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PMID: 23451179
DOI: 10.1371/journal.pone.0057172

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