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Article

Autophagy regulates the cancer stem cell phenotype of head and neck squamous cell carcinoma through the noncanonical FOXO3/SOX2 axis.

Oncogene - 1 Jan 2022

Chen Yang, Zhao Hui, Liang Weilian, Jiang Erhui, Zhou Xiaocheng, Shao Zhe, Liu Ke, Shang Zhengjun

Abstract excerpt

Autophagy is an essential catabolic process that orchestrates cellular homeostasis and plays dual roles in tumor promotion and suppression. However, the mechanism by which autophagy affects the self-renewal of cancer stem cells (CSCs) remains unclear. In this study, we investigated whether autophagy activation contributes to CSC properties of head and neck squamous cell carcinoma (HNSCC). The results showed that...

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Share to Carcinoma, Squamous Cell

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Forkhead Box Protein O3

Share to Gene Expression Regulation, Neoplastic

Share to Head and Neck Neoplasms

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Share to SOXB1 Transcription Factors

Share to Squamous Cell Carcinoma of Head and Neck

Source

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Identifiers

PMID: 34795388
DOI: 10.1038/s41388-021-02115-7
PMCID: PMC8799462

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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