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Article

Chronic lymphocytic leukemia with IGH/BCL2 fusion and clonal heterogeneity: phenotypic and molecular profiling analysis of a rare case.

Annals of hematology - 11 Feb 2026

Zhang Ting, Liu Dan, Ren Fanggang, Hao Jian, Ye Feng, Chen Yakun, Qiao Bianbian, Zhang Yaofang, Chang Jianmei, Wang Hongwei, Xu Zhifang

Abstract excerpt

Clonal heterogeneity within chronic lymphocytic leukemia (CLL) has been increasingly recognized as a factor that may influence disease progression, treatment response, and prognosis. Here, we report a rare case of CLL with two distinct B-cell populations displaying distinct immunophenotypic characteristics, genetic mutations, and genetic evolution. The two aberrant mature B cell populations were identified in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Leukemia, Lymphocytic, Chronic, B-Cell

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Source

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Identifiers

PMID: 41667896
DOI: 10.1007/s00277-026-06877-6
PMCID: PMC12891074

Genes

BCL2
CD200
CD5
BCORL1
EP300
IGH
KMT2A
KMT2C
KMT2D
NOTCH1
TNFAIP3
TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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