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Article

HIV-Specific CD8<sup>+</sup>T Cells from Elite Controllers Are Primed for Survival

1 Mar 2013

Abstract excerpt

HIV-specific cytotoxic T lymphocytes (CTL) are preferentially primed for apoptosis, and this may represent a viral escape mechanism. We hypothesized that HIV-infected individuals that control virus to undetectable levels without antiretroviral therapy (ART) (elite controllers [EC]) have the capacity to upregulate survival factors that allow them to resist apoptosis. To address this, we performed cross-sectional...

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PMID: 23449791
DOI: 10.1128/jvi.02379-12

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