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Motor neuron disease-associated loss of nuclear TDP-43 is linked to DNA double-strand break repair defects

15 Feb 2019

Abstract excerpt

Significance Amyotrophic lateral sclerosis (ALS) is a devastating, motor neuron degenerative disease without any cure to date. About 95% of ALS patients feature abnormalities in the RNA/DNA binding protein TDP-43, involving its nucleus-cytoplasmic mislocalization in spinal motor neurons. How TDP-43 pathology triggers neuronal apoptosis remains unclear. Here, we report that TDP-43 participates in the DNA damage...

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PMID: 30770445
DOI: 10.1073/pnas.1818415116

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