Article
Genome-wide association study of susceptibility to acute respiratory distress syndrome.
EBioMedicine - 1 Oct 2025
Guillen-Guio Beatriz, Suarez-Pajes Eva, Tosco-Herrera Eva, Hernandez-Beeftink Tamara, Lorenzo-Salazar Jose Miguel, Chang Diana, González-Montelongo Rafaela, Rubio-Rodríguez Luis A, Leavy Olivia C, Allen Richard J, Corrales Almudena, Cruz Raquel, Bardají-Carrillo Miguel, Carracedo Angel, Tamayo Eduardo, Kerchberger V Eric, Ware Lorraine B, Yaspan Brian L, Scholz Markus, Scherag André, Villar Jesús, Wain Louise V, Flores Carlos
Abstract excerpt
BACKGROUND: Acute respiratory distress syndrome (ARDS) is a severe inflammatory process of the lung, often due to sepsis, and poses significant mortality burden in intensive care units. Here we conducted a genome-wide association study (GWAS) of ARDS to identify genetic risk loci that can help guide the development of new therapeutic options. METHODS: We performed a case-control GWAS in 716 cases with ARDS,...
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