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Article

CD137 Stimulation Enhances Cetuximab-Induced Natural Killer: Dendritic Cell Priming of Antitumor T-Cell Immunity in Patients with Head and Neck Cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Feb 2017

Srivastava Raghvendra M, Trivedi Sumita, Concha-Benavente Fernando, Gibson Sandra P, Reeder Carly, Ferrone Soldano, Ferris Robert L

Abstract excerpt

PURPOSE: Cetuximab, an EGFR-specific antibody (mAb), modestly improves clinical outcome in patients with head and neck cancer (HNC). Cetuximab mediates natural killer (NK) cell:dendritic cell (DC) cross-talk by cross-linking FcγRIIIa, which is important for inducing antitumor cellular immunity. Cetuximab-activated NK cells upregulate the costimulatory receptor CD137 (4-1BB), which, when triggered by agonistic mAb...

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Share to Antigen Presentation
Share to Antigens, Neoplasm

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Antineoplastic Agents, Immunological

Share to Cetuximab

Share to Head and Neck Neoplasms

Share to Lymphocytes, Tumor-Infiltrating

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Share to Receptors, IgG

Source

Open in PubMed Open full text

Identifiers

PMID: 27496866
DOI: 10.1158/1078-0432.CCR-16-0879
PMCID: PMC5290200

Genes

EGFR
TAP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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