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Article

STAT1-Induced HLA Class I Upregulation Enhances Immunogenicity and Clinical Response to Anti-EGFR mAb Cetuximab Therapy in HNC Patients.

Cancer immunology research - 1 Aug 2015

Srivastava Raghvendra M, Trivedi Sumita, Concha-Benavente Fernando, Hyun-Bae Jie, Wang Lin, Seethala Raja R, Branstetter Barton F, Ferrone Soldano, Ferris Robert L

Abstract excerpt

The goal of this study was to characterize the molecular mechanisms underlying cetuximab-mediated upregulation of HLA class I antigen-processing machinery components in head and neck cancer (HNC) cells and to determine the clinical significance of these changes in cetuximab-treated HNC patients. Flow cytometry, signaling studies, and chromatin immunoprecipitation (ChIP) assays were performed using HNC cells...

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Topics

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Protein Tyrosine Phosphatase, Non-Receptor Type 11

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Source

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Identifiers

PMID: 25972070
DOI: 10.1158/2326-6066.CIR-15-0053
PMCID: PMC4526378

Genes

EGFR
STAT1
TAP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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