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Article

The [4Fe-4S] cluster of sulfurtransferase TtuA desulfurizes TtuB during tRNA modification in Thermus thermophilus.

Communications biology - 7 Apr 2020

Chen Minghao, Ishizaka Masato, Narai Shun, Horitani Masaki, Shigi Naoki, Yao Min, Tanaka Yoshikazu

Abstract excerpt

TtuA and TtuB are the sulfurtransferase and sulfur donor proteins, respectively, for biosynthesis of 2-thioribothymidine (s2T) at position 54 of transfer RNA (tRNA), which is responsible for adaptation to high temperature environments in Thermus thermophilus. The enzymatic activity of TtuA requires an iron-sulfur (Fe-S) cluster, by which a sulfur atom supplied by TtuB is transferred to the tRNA substrate. Here,...

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PMID: 32265486
DOI: 10.1038/s42003-020-0895-3
PMCID: PMC7138817

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