Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

MED12 exon 2 mutations in histopathological uterine leiomyoma variants.

European journal of human genetics : EJHG - 1 Nov 2013

Mäkinen Netta, Vahteristo Pia, Kämpjärvi Kati, Arola Johanna, Bützow Ralf, Aaltonen Lauri A

Abstract excerpt

Uterine leiomyomas, or fibroids, are the most common human tumors. Based on histopathology, they can be divided into common leiomyomas and various relatively rare subtypes that mimic malignancy in one or more aspects. Recently, we showed that exon 2 of mediator complex subunit 12 (MED12) is mutated in up to 70% of common fibroids. To investigate the frequency of MED12 exon 2 mutations in histopathological uterine...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA Mutational Analysis
Share to Exons
Share to Fumarate Hydratase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Leiomyoma

Share to Loss of Heterozygosity

Share to Mediator Complex

Share to Tissue Banks

Share to Uterine Neoplasms

Source

Open in PubMed Open full text

Identifiers

PMID: 23443020
DOI: 10.1038/ejhg.2013.33
PMCID: PMC3798840

Genes

MED12

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

MED12 exon 2 mutations in histopathological uterine leiomyoma variants.PMID 23443020Read ↗

MED12 mutations and FH inactivation are mutually exclusive in uterine leiomyomas.Semantic proximity Read ↗

The Mediator Complex Subunit 12 (MED-12) Gene and Uterine Fibroids: a Systematic Review.Semantic proximity Read ↗

Systematic molecular and clinical analysis of uterine leiomyomas from fertile-aged women undergoing myomectomy.Semantic proximity Read ↗

Integrated data analysis reveals uterine leiomyoma subtypes with distinct driver pathways and biomarkers.Semantic proximity Read ↗

MED12 mutation frequency in unselected sporadic uterine leiomyomas.Semantic proximity Read ↗

Missense mutations in exon 2 of the MED12 gene are involved in IGF-2 overexpression in uterine leiomyomaSemantic proximity Read ↗

3'RNA and whole-genome sequencing of archival uterine leiomyomas reveal a tumor subtype with chromosomal rearrangements affecting either HMGA2, HMGA1, or PLAG1.Semantic proximity Read ↗

MED12, the mediator complex subunit 12 gene, is mutated at high frequency in uterine leiomyomas.Semantic proximity Read ↗

Med12 gain-of-function mutation causes leiomyomas and genomic instabilitySemantic proximity Read ↗

Exomic landscape of MED12 mutation-negative and -positive uterine leiomyomas.Semantic proximity Read ↗

Multiple clinical characteristics separate MED12-mutation-positive and -negative uterine leiomyomas.Semantic proximity Read ↗

UTERINE FIBROIDS.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.