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Article

MED12 mutations and FH inactivation are mutually exclusive in uterine leiomyomas.

British journal of cancer - 14 Jun 2016

Kämpjärvi Kati, Mäkinen Netta, Mehine Miika, Välipakka Salla, Uimari Outi, Pitkänen Esa, Heinonen Hanna-Riikka, Heikkinen Tuomas, Tolvanen Jaana, Ahtikoski Anne, Frizzell Norma, Sarvilinna Nanna, Sjöberg Jari, Bützow Ralf, Aaltonen Lauri A, Vahteristo Pia

Abstract excerpt

BACKGROUND: Uterine leiomyomas from hereditary leiomyomatosis and renal cell cancer (HLRCC) patients are driven by fumarate hydratase (FH) inactivation or occasionally by mediator complex subunit 12 (MED12) mutations. The aim of this study was to analyse whether MED12 mutations and FH inactivation are mutually exclusive and to determine the contribution of MED12 mutations on HLRCC patients' myomagenesis. METHODS:...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27187686
DOI: 10.1038/bjc.2016.130
PMCID: PMC4984459

Genes

MED12

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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