Article
Myoblasts and embryonic stem cells differentially engraft in a mouse model of genetic dilated cardiomyopathy.
Molecular therapy : the journal of the American Society of Gene Therapy - 1 May 2013
Catelain Cyril, Riveron Stéphanie, Papadopoulos Aurélie, Mougenot Nathalie, Jacquet Adeline, Vauchez Karine, Yada Erica, Pucéat Michel, Fiszman Marc, Butler-Browne Gillian, Bonne Gisèle, Vilquin Jean-Thomas
Abstract excerpt
The functional and architectural benefits of embryonic stem cells (ESC) and myoblasts (Mb) transplantations into infarcted myocardium have been investigated extensively. Whereas ESC repopulated fibrotic areas and contributed to myocardial regeneration, Mb exerted their effects through paracrine secretions and scar remodeling. This therapeutic perspective, however, has been less explored in the setting of...
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