Article
Fibroblasts from human postmyocardial infarction scars acquire properties of cardiomyocytes after transduction with a recombinant myocardin gene.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Oct 2007
van Tuyn John, Pijnappels Daniël A, de Vries Antoine A F, de Vries Ingrid, van der Velde-van Dijke Ietje, Knaän-Shanzer Shoshan, van der Laarse Arnoud, Schalij Martin J, Atsma Douwe E
Abstract excerpt
Myocardial scar formation impairs heart function by inducing cardiac remodeling, decreasing myocardial compliance, and compromising normal electrical conduction. Conversion of myocardial scar fibroblasts (MSFs) into (functional) cardiomyocytes may be an effective alternative treatment to limit loss of cardiac performance after myocardial injury. In this study, we investigated whether the phenotype of MSFs can be...
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