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Article

Bem1p is a positive regulator of the homotypic fusion of yeast vacuoles.

The Journal of biological chemistry - 15 Sept 2006

Xu Hao, Wickner William

Abstract excerpt

Docked vacuoles are believed to undergo rapid lipid mixing during hemifusion and then a slow, rate-limiting completion of fusion and mixing of lumenal contents. Previous genomic analysis has suggested that Bem1p, a scaffold protein critical for cell polarity, may support vacuole fusion. We now report that bem1Delta strains have fragmented vacuoles (vps class B and C). During in vitro fusion reactions, vacuoles...

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Share to Adaptor Proteins, Signal Transducing
Share to Genes, Fungal
Share to Lipids

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16854988
DOI: 10.1074/jbc.M605592200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Bem1p is a positive regulator of the homotypic fusion of yeast vacuoles.PMID 16854988Read ↗

Identification of genes affecting vacuole membrane fragmentation in Saccharomyces cerevisiae.Semantic proximity Read ↗

The SM protein Vps33 and the t-SNARE H(abc) domain promote fusion pore opening.Semantic proximity Read ↗

The vacuolar kinase Yck3 maintains organelle fragmentation by regulating the HOPS tethering complex.Semantic proximity Read ↗

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Homotypic vacuole fusion in yeast requires organelle acidification and not the V-ATPase membrane domain.Semantic proximity Read ↗

The GTPase effector domain sequence of the Dnm1p GTPase regulates self-assembly and controls a rate-limiting step in mitochondrial fission.Semantic proximity Read ↗

Phospholipid association is essential for dynamin-related protein Mgm1 to function in mitochondrial membrane fusion.Semantic proximity Read ↗

Remodeling of organelle-bound actin is required for yeast vacuole fusion.Semantic proximity Read ↗

Acyl-CoA-binding protein, Acb1p, is required for normal vacuole function and ceramide synthesis in Saccharomyces cerevisiae.Semantic proximity Read ↗

The lipid composition and physical properties of the yeast vacuole affect the hemifusion-fusion transition.Semantic proximity Read ↗

Self-interaction of a SNARE transmembrane domain promotes the hemifusion-to-fusion transition.Semantic proximity Read ↗

Synthesis of sphingolipids with very long chain fatty acids but not ergosterol is required for routing of newly synthesized plasma membrane ATPase to the cell surface of yeast.Semantic proximity Read ↗

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