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Article

Rab6a/a' are important Golgi regulators of pro-inflammatory TNF secretion in macrophages.

PloS one - 1 Jan 2013

Micaroni Massimo, Stanley Amanda C, Khromykh Tatiana, Venturato Juliana, Wong Colin X F, Lim Jet P, Marsh Brad J, Storrie Brian, Gleeson Paul A, Stow Jennifer L

Abstract excerpt

Lipopolysaccharide (LPS)-activated macrophages secrete pro-inflammatory cytokines, including tumor necrosis factor (TNF) to elicit innate immune responses. Secretion of these cytokines is also a major contributing factor in chronic inflammatory disease. In previous studies we have begun to elucidate the pathways and molecules that mediate the intracellular trafficking and secretion of TNF. Rab6a and Rab6a'...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23437303
DOI: 10.1371/journal.pone.0057034
PMCID: PMC3578815

Genes

TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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