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Article

Bmi1 enhances tumorigenicity and cancer stem cell function in pancreatic adenocarcinoma.

PloS one - 1 Jan 2013

Proctor Erica, Waghray Meghna, Lee Cheong Jun, Heidt David G, Yalamanchili Malica, Li Chenwei, Bednar Filip, Simeone Diane M

Abstract excerpt

BACKGROUND: Bmi1 is an integral component of the Polycomb Repressive Complex 1 (PRC1) and is involved in the pathogenesis of multiple cancers. It also plays a key role in the functioning of endogenous stem cells and cancer stem cells. Previous work implicated a role for cancer stem cells in the pathogenesis of pancreatic cancer. We hypothesized that Bmi1 plays an integral role in enhancing pancreatic...

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Identifiers

PMID: 23437065
DOI: 10.1371/journal.pone.0055820
PMCID: PMC3577834

Genes

PRC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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