Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

MicroRNA let-7d regulates the TLX/microRNA-9 cascade to control neural cell fate and neurogenesis.

Scientific reports - 1 Jan 2013

Zhao Chunnian, Sun GuoQiang, Ye Peng, Li Shengxiu, Shi Yanhong

Abstract excerpt

MicroRNAs have important functions in the nervous system through post-transcriptional regulation of neurogenesis genes. Here we show that microRNA let-7d, which has been implicated in cocaine addiction and other neurological disorders, targets the neural stem cell regulator TLX. Overexpression of let-7d in vivo reduced neural stem cell proliferation and promoted premature neuronal differentiation and migration, a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Dogs
Share to 3' Untranslated Regions
Share to Cell Movement

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Isoantigens

Share to Neural Stem Cells

Share to Neurogenesis

Share to RNA Interference

Share to RNA, Small Interfering

Source

Open in PubMed Open full text

Identifiers

PMID: 23435502
DOI: 10.1038/srep01329
PMCID: PMC3580325

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

MicroRNA let-7d regulates the TLX/microRNA-9 cascade to control neural cell fate and neurogenesis.PMID 23435502Read ↗

let‐7 regulates radial migration of new‐born neurons through positive regulation of autophagySemantic proximity Read ↗

MiR-9, miR-153 and miR-124 are down-regulated by acute exposure to cocaine in a dopaminergic cell model and may contribute to cocaine dependence.Semantic proximity Read ↗

Regulation of Opioid Tolerance by let-7 Family MicroRNA Targeting the μ Opioid ReceptorSemantic proximity Read ↗

MiR-124 synergism with ELAVL3 enhances target gene expression to promote neuronal maturitySemantic proximity Read ↗

MicroRNA-9 reveals regional diversity of neural progenitors along the anterior-posterior axis.Semantic proximity Read ↗

miR-7a regulation of Pax6 controls spatial origin of forebrain dopaminergic neurons.Semantic proximity Read ↗

MicroRNA Profiling During Neural Differentiation of Induced Pluripotent Stem CellsSemantic proximity Read ↗

Mesenchymal Stem Cells Deliver Exogenous miRNAs to Neural Cells and Induce Their Differentiation and Glutamate Transporter ExpressionSemantic proximity Read ↗

Reciprocal actions of REST and a microRNA promote neuronal identity.Semantic proximity Read ↗

The Dlx5 and Foxg1 transcription factors, linked via miRNA-9 and -200, are required for the development of the olfactory and GnRH system.Semantic proximity Read ↗

The miR-20-Rest-Wnt signaling axis regulates neural progenitor cell differentiationSemantic proximity Read ↗

Notch Inhibition Enhances Morphological Reprogramming of microRNA-Induced Human NeuronsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.