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The Dlx5 and Foxg1 transcription factors, linked via miRNA-9 and -200, are required for the development of the olfactory and GnRH system.

Molecular and cellular neurosciences - 1 Sept 2015

Garaffo Giulia, Conte Daniele, Provero Paolo, Tomaiuolo Daniela, Luo Zheng, Pinciroli Patrizia, Peano Clelia, D'Atri Ilaria, Gitton Yorick, Etzion Talya, Gothilf Yoav, Gays Dafne, Santoro Massimo M, Merlo Giorgio R

Abstract excerpt

During neuronal development and maturation, microRNAs (miRs) play diverse functions ranging from early patterning, proliferation and commitment to differentiation, survival, homeostasis, activity and plasticity of more mature and adult neurons. The role of miRs in the differentiation of olfactory receptor neurons (ORNs) is emerging from the conditional inactivation of Dicer in immature ORN, and the depletion of...

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Identifiers

PMID: 25937343
DOI: 10.1016/j.mcn.2015.04.007
PMCID: PMC4604252

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