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Article

Characterization of Clinical Phenotype to Glial Fibrillary Acidic Protein Concentrations in Alexander Disease.

Annals of clinical and translational neurology - 1 Jun 2026

Waldman Amy T, Takanohashi Asako, Joung Joshua Y, Liu Geraldine W, Arnold Kaley, Pizzino Amy, Faig Walter, Woidill Sarah, Narula Sona, Vanderver Adeline L

Abstract excerpt

OBJECTIVE: To determine the concentration of glial fibrillary acidic protein (GFAP) in cerebrospinal fluid (CSF) and plasma in Alexander disease (AxD) and whether GFAP levels are predictive of disease phenotypes. METHODS: CSF and plasma were collected (longitudinally when available) from AxD participants and non-AxD controls. The concentration of GFAP was compared between groups using Wilcoxon rank sum test. The...

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Identifiers

PMID: 41513585
DOI: 10.1002/acn3.70305
PMCID: PMC13251449

Genes

GFAP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

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Research trail→

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Characterization of Clinical Phenotype to Glial Fibrillary Acidic Protein Concentrations in Alexander Disease.PMID 41513585Read ↗

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Alexander disease: models, mechanisms, and medicine.Semantic proximity Read ↗

[Clinical characteristics and diagnostic criteria on Alexander disease].Semantic proximity Read ↗

Type I Alexander disease: Update and validation of the clinical evolution-based classification.Semantic proximity Read ↗

Increased levels of GFAP in the cerebrospinal fluid in three subtypes of genetically confirmed Alexander disease.Semantic proximity Read ↗

Recessively-Inherited Adult-Onset Alexander Disease Caused by a Homozygous Mutation in the GFAP Gene.Semantic proximity Read ↗

Genotype-Phenotype Association for 14 GFAP Variants in Alexander DiseaseSemantic proximity Read ↗

De novo mutations in GFAP cause Alexander disease: clinical features, fMRI and functional analysisSemantic proximity Read ↗

Pexidartinib treatment in Alexander disease model mice reduces macrophage numbers and increases glial fibrillary acidic protein levels, yet has minimal impact on other disease phenotypes.Semantic proximity Read ↗

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