Article
A conditionally replicating adenovirus with strict selectivity in killing cells expressing epidermal growth factor receptor.
Virology - 25 Apr 2007
Carette Jan E, Graat Harm C A, Schagen Frederik H E, Mastenbroek D C Jeroen, Rots Marianne G, Haisma Hidde J, Groothuis Geny M M, Schaap Gerard R, Bras Johannes, Kaspers Gertjan J L, Wuisman Paul I J M, Gerritsen Winald R, van Beusechem Victor W
Abstract excerpt
Virotherapy of cancer using oncolytic adenoviruses has shown promise in both preclinical and clinical settings. One important challenge to reach the full therapeutic potential of oncolytic adenoviruses is accomplishing efficient infection of cancer cells and avoiding uptake by normal tissue through tropism modification. Towards this goal, we constructed and characterized an oncolytic adenovirus, carrying mutated...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.