Article

FAP-retargeted Ad5 enables <i>in vivo</i> gene delivery to stromal cells in the tumor microenvironment

2022-12-19

Abstract excerpt

Fibroblast activation protein (FAP) is a cell surface serine protease that is highly expressed on reactive stromal fibroblasts, such as cancer-associated fibroblasts (CAFs), and generally absent in healthy adult tissues. FAP expression in the tumor stroma has been detected in more than 90% of all carcinomas, rendering CAFs excellent target cells for a tumor site-specific adenoviral delivery of cancer therapeutics....

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Literature Corpus work: bf4cfc84-04bb-59a3-88bb-2be84a8d1230
DOI: 10.1101/2022.12.19.520931

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