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Article

Liver receptor homolog 1 is essential for ovulation.

Genes & development - 15 Jul 2008

Duggavathi Rajesha, Volle David H, Mataki Chikage, Antal Maria C, Messaddeq Nadia, Auwerx Johan, Murphy Bruce D, Schoonjans Kristina

Abstract excerpt

Female fertility requires normal ovarian follicular growth and ovulation. The nuclear receptor liver receptor homolog 1 has been implicated in processes as diverse as bile acid metabolism, steroidogenesis, and cell proliferation. In the ovary, Lrh1 is expressed exclusively in granulosa and luteal cells. Using somatic targeted mutagenesis, we show that mice lacking Lrh1 in granulosa cells are sterile, due to...

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Identifiers

PMID: 18628394
DOI: 10.1101/gad.472008
PMCID: PMC2492734

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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