Article
TATA box polymorphisms in human gene promoters and associated hereditary pathologies.
Biochemistry. Biokhimiia - 1 Feb 2009
Savinkova L K, Ponomarenko M P, Ponomarenko P M, Drachkova I A, Lysova M V, Arshinova T V, Kolchanov N A
Abstract excerpt
TATA-binding protein (TBP) is the first basal factor that recognizes and binds a TATA box on TATA-containing gene promoters transcribed by RNA polymerase II. Data available in the literature are indicative of admissible variability of the TATA box. The TATA box flanking sequences can influence TBP affinity as well as the level of basal and activated transcription. The possibility of mediated involvement in in...
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