Article
Identification of colorectal cancer patients with tumors carrying the TP53 mutation on the codon 72 proline allele that benefited most from 5-fluorouracil (5-FU) based postoperative chemotherapy.
BMC cancer - 2 Dec 2009
Godai Ten-i, Suda Tetsuji, Sugano Nobuhiro, Tsuchida Kazuhito, Shiozawa Manabu, Sekiguchi Hironobu, Sekiyama Akiko, Yoshihara Mitsuyo, Matsukuma Shoichi, Sakuma Yuji, Tsuchiya Eiju, Kameda Yoichi, Akaike Makoto, Miyagi Yohei
Abstract excerpt
BACKGROUND: Although postoperative chemotherapy is widely accepted as the standard modality for Dukes' stage C or earlier stage colorectal cancer (CRC) patients, biomarkers to predict those who may benefit from the therapy have not been identified. Previous in vitro and clinical investigations re...
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