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Article

SET protein up-regulated testosterone production in the cultured preantral follicles

19 Feb 2013

Abstract excerpt

BACKGROUND: We found previously that the expression of SET gene was up-regulated in polycystic ovaries. Evidences suggested that SET protein was essential for regulating both the promoter activity of CYP17A1 and the biological activity of P450c17. In this study, we explored whether SET regulated androgen production in preantral follicles. METHODS: The mouse preantral follicles were cultured in vitro. Testosterone...

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Share to Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
Share to Ovarian function and disorders
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PMID: 23421880
DOI: 10.1186/1477-7827-11-9

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