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Article

Augmented androgen production is a stable steroidogenic phenotype of propagated theca cells from polycystic ovaries.

Molecular endocrinology (Baltimore, Md.) - 1 Jun 1999

Nelson V L, Legro R S, Strauss J F, McAllister J M

Abstract excerpt

To test the hypothesis that the hyperandrogenemia associated with polycystic ovary syndrome (PCOS) results from an intrinsic abnormality in ovarian theca cell steroidogenesis, we examined steroid hormone production, steroidogenic enzyme activity, and mRNA expression in normal and PCOS theca cells propagated in long-term culture. Progesterone (P4), 17alpha-hydroxyprogesterone (17OHP4), and testosterone (T)...

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Identifiers

PMID: 10379893
DOI: 10.1210/mend.13.6.0311

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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