Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Conversion of the LIMA1 tumour suppressor into an oncogenic LMO-like protein by API2–MALT1 in MALT lymphoma

8 Jan 2015

Abstract excerpt

MALT1 is the only known paracaspase and is a critical mediator of B- and T-cell receptor signalling. The function of the MALT1 gene is subverted by oncogenic chimeric fusions arising from the recurrent t(11;18)(q21;q21) aberration, which is the most frequent translocation in mucosa-associated lymphoid tissue (MALT) lymphoma. API2–MALT1-positive MALT lymphomas manifest antibiotic resistance and aggressive clinical...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CAR-T cell therapy research
Share to Lymphoma Diagnosis and Treatment
Share to Ubiquitin and proteasome pathways

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 25569716
DOI: 10.1038/ncomms6908

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Conversion of the LIMA1 tumour suppressor into an oncogenic LMO-like protein by API2–MALT1 in MALT lymphomaPMID 25569716Read ↗

Constitutive NF-kappaB activation by the t(11;18)(q21;q21) product in MALT lymphoma is linked to deregulated ubiquitin ligase activity.Semantic proximity Read ↗

The protease activity of the paracaspase MALT1 is controlled by monoubiquitination.Semantic proximity Read ↗

Recent Advances in the Genetic of MALT LymphomasSemantic proximity Read ↗

The origin and targeting of mucosa-associated lymphoid tissue lymphomas.Semantic proximity Read ↗

Oncogene-induced MALT1 protease activity drives posttranscriptional gene expression in malignant lymphomasSemantic proximity Read ↗

The paracaspase MALT1 cleaves HOIL1 reducing linear ubiquitination by LUBAC to dampen lymphocyte NF-κB signalling.Semantic proximity Read ↗

A dual role for the API2 moiety in API2-MALT1-dependent NF-kappaB activation: heterotypic oligomerization and TRAF2 recruitment.Semantic proximity Read ↗

The inhibitor of apoptosis protein fusion c-IAP2.MALT1 stimulates NF-kappaB activation independently of TRAF1 AND TRAF2.Semantic proximity Read ↗

The Paracaspase MALT1.Semantic proximity Read ↗

Molecular pathogenesis and histologic and clinical features of extranodal marginal zone lymphomas of mucosa-associated lymphoid tissue type.Semantic proximity Read ↗

Role of the CARMA1/BCL10/MALT1 complex in lymphoid malignanciesSemantic proximity Read ↗

MALT lymphoma: many roads lead to nuclear factor-κb activationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.