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Article

Computational screening and molecular dynamics simulation of disease associated nsSNPs in CENP-E.

Mutation research - 1 Jan 2000

Kumar Ambuj, Purohit Rituraj

Abstract excerpt

Aneuploidy and chromosomal instability (CIN) are hallmarks of most solid tumors. Mutations in centroemere proteins have been observed in promoting aneuploidy and tumorigenesis. Recent studies reported that Centromere-associated protein-E (CENP-E) is involved in inducing cancers. In this study we investigated the pathogenic effect of 132 nsSNPs reported in CENP-E using computational platform. Y63H point mutation...

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Identifiers

PMID: 22974711
DOI: 10.1016/j.mrfmmm.2012.08.005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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