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Article

Influence of Opa1 Mutation on Survival and Function of Retinal Ganglion Cells.

Investigative ophthalmology & visual science - 1 Jul 2015

González-Menéndez Irene, Reinhard Katja, Tolivia Jorge, Wissinger Bernd, Münch Thomas A

Abstract excerpt

PURPOSE: Mutations in the OPA1 gene cause autosomal dominant optic atrophy (ADOA), a visual disorder associated with degeneration of retinal ganglion cells (RGCs). Here, we characterized the disease progression in a homologous mouse model B6;C3-Opa1 329-355del and asked whether the pronounced cell death affects certain RGC types more than others. METHODS: The influence of the Opa1 mutation was assessed by...

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Source

Identifiers

PMID: 26218912
DOI: 10.1167/iovs.15-16743

Genes

OPA1

Provenance

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