Article
Extracellular signal-regulated kinase and glycogen synthase kinase 3β regulate gephyrin postsynaptic aggregation and GABAergic synaptic function in a calpain-dependent mechanism.
The Journal of biological chemistry - 5 Apr 2013
Tyagarajan Shiva K, Ghosh Himanish, Yévenes Gonzalo E, Imanishi Susumu Y, Zeilhofer Hanns Ulrich, Gerrits Bertran, Fritschy Jean-Marc
Abstract excerpt
Molecular mechanisms of plasticity at GABAergic synapses are currently poorly understood. To identify signaling cascades that converge onto GABAergic postsynaptic density proteins, we performed MS analysis using gephyrin isolated from rat brain and identified multiple novel phosphorylation and acetylation residues on gephyrin. Here, we report the characterization of one of these phosphoresidues, Ser-268, which...
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