Article
Elovl4 5-bp-deletion knock-in mice develop progressive photoreceptor degeneration.
Investigative ophthalmology & visual science - 1 Oct 2006
Vasireddy Vidyullatha, Jablonski Monica M, Mandal Md Nawajes A, Raz-Prag Dorit, Wang Xiaofei F, Nizol Lesli, Iannaccone Alessandro, Musch David C, Bush Ronald A, Salem Norman, Sieving Paul A, Ayyagari Radha
Abstract excerpt
PURPOSE: To develop and characterize a heterozygous knock-in mouse model carrying the 5-bp deletion in Elovl4 (E_mut+/-) and to study the pathology underlying Stargardt-like macular degeneration (STGD3). METHODS: E_mut+/- mice were generated by targeting a 5-bp deletion (AACTT) in the Elovl4 gene by homologous recombination. E_mut+/- mice of age 2 to 18 months and age-matched wild-type (Wt) littermate control...
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