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Article

Epigenomics and metabolomics reveal the mechanism of the APOA2-saturated fat intake interaction affecting obesity.

The American journal of clinical nutrition - 1 Jul 2018

Lai Chao-Qiang, Smith Caren E, Parnell Laurence D, Lee Yu-Chi, Corella Dolores, Hopkins Paul, Hidalgo Bertha A, Aslibekyan Stella, Province Michael A, Absher Devin, Arnett Donna K, Tucker Katherine L, Ordovas Jose M

Abstract excerpt

Background: The putative functional variant -265T>C (rs5082) within the APOA2 promoter has shown consistent interactions with saturated fatty acid (SFA) intake to influence the risk of obesity. Objective: The aim of this study was to implement an integrative approach to characterize the molecular basis of this interaction. Design: We conducted an epigenome-wide scan on 80 participants carrying either the rs5082...

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Identifiers

PMID: 29901700
DOI: 10.1093/ajcn/nqy081
PMCID: PMC6454512

Genes

APOA2

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